Retrograde nerve growth factor signaling modulates tooth mechanical hyperalgesia induced by orthodontic tooth movement via acid-sensing ion channel 3

• Main Authors: Meiya Gao (Author), Xinyu Yan (Author), Yanzhu Lu (Author), Linghuan Ren (Author), Shizhen Zhang (Author), Xiaoqi Zhang (Author), Qianyun Kuang (Author), Lu Liu (Author), Jing Zhou (Author), Yan Wang (Author), Wenli Lai (Author), Hu Long (Author)
• Format: Book
• Published: Nature Publishing Group, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in periodontium and may modulate tooth mechanical hyperalgesia. The objectives were to examine the role of NGF in toot...