Pharmacokinetic Modeling to Guide Preclinical Development of an Islatravir-Eluting Reservoir-Style Biodegradable Implant for Long-Acting HIV PrEP

• Main Authors: Talisa S. Kinsale (Author), Mackenzie L. Cottrell (Author), Linying Li (Author), Rhonda Brand (Author), Greg Gatto (Author), Ellen Luecke (Author), Chasity Norton (Author), Archana Krovi (Author), Julie B. Dumond (Author), Gauri Rao (Author), Shekhar Yeshwante (Author), Brian Van Horne (Author), Ariane Van Der Straten (Author), Angela D. M. Kashuba (Author), Leah M. Johnson (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long-acting injectable cabotegravir is more effective than daily oral PrEP at preventing HIV transmission due to improved adherence, but requires bi-monthly large-volume intramuscular injections. Subcutaneous (SC) contraceptive implants can be formulated with antiretrovirals for extended-duration HI...