Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome
<p>Abstract</p> <p>Tocilizumab (TCZ) is the first FDA- approved treatment for systemic juvenile idiopathic arthritis (sJIA). We report 3 cases of cytopenias in children with sJIA treated with TCZ. Two of the children who developed significant cytopenias shortly after initiation of...
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| Format: | Book |
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BMC,
2012-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_5e42ebc3b3d64b5897e37dba377ed30b | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Kessler Elizabeth A |e author |
| 700 | 1 | 0 | |a Vora Sheetal S |e author |
| 700 | 1 | 0 | |a Verbsky James W |e author |
| 245 | 0 | 0 | |a Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome |
| 260 | |b BMC, |c 2012-08-01T00:00:00Z. | ||
| 500 | |a 10.1186/1546-0096-10-30 | ||
| 500 | |a 1546-0096 | ||
| 520 | |a <p>Abstract</p> <p>Tocilizumab (TCZ) is the first FDA- approved treatment for systemic juvenile idiopathic arthritis (sJIA). We report 3 cases of cytopenias in children with sJIA treated with TCZ. Two of the children who developed significant cytopenias shortly after initiation of TCZ had a history of macrophage activation syndrome. We raise the possibility that patients with a tendency towards MAS have an increased risk of developing cytopenias when treated with tocilizumab.</p> | ||
| 546 | |a EN | ||
| 690 | |a Juvenile idiopathic arthritis | ||
| 690 | |a Macrophage activation syndrome | ||
| 690 | |a Tocilizumab | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 690 | |a Diseases of the musculoskeletal system | ||
| 690 | |a RC925-935 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pediatric Rheumatology Online Journal, Vol 10, Iss 1, p 30 (2012) | |
| 787 | 0 | |n http://www.ped-rheum.com/content/10/1/30 | |
| 787 | 0 | |n https://doaj.org/toc/1546-0096 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5e42ebc3b3d64b5897e37dba377ed30b |z Connect to this object online. |