Phase 3 trials of new antiretrovirals are not representative of the global HIV epidemic

• Main Authors: Toby Pepperrell (Author), Andrew Hill (Author), Michelle Moorhouse (Author), Polly Clayden (Author), Kaitlyn McCann (Author), Simiso Sokhela (Author), Celicia Serenata (Author), Willem Daniel Francois Venter (Author)
• Format: Book
• Published: Elsevier, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: People living with HIV (PLWH) are mainly African or Asian, the majority female. In contrast, pharmaceutical companies typically conduct phase 3 regulatory randomised controlled trials (RCTs) in high-income countries (HICs), where PLWH are mainly white males. Regulatory authorities can...