Double blind clinical trial on a lactose-free and a lactose-containing formula in the treatment of acute diarrhea in children
Background Lactose intolerance is a common complication of diarrhea in young children particularly that due to rotaviral infec- tion. A meta-analysis study evaluated the use of undiluted lactose containing formula or cow's milk during an episode of diarrhea. It was concluded that routine diluti...
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Indonesian Pediatric Society Publishing House,
2016-10-01T00:00:00Z.
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| Summary: | Background Lactose intolerance is a common complication of diarrhea in young children particularly that due to rotaviral infec- tion. A meta-analysis study evaluated the use of undiluted lactose containing formula or cow's milk during an episode of diarrhea. It was concluded that routine dilution of milk and the use of lactose- free milk formula are not necessary. Objective To evaluate the effect of lactose free formula compared with lactose-containing milk formula during acute diarrheal episode in outpatient setting. Methods A total of 56 children with acute diarrhea with mild-mod- erate or no dehydration attending to the outpatient clinic were ran- domly assigned to receive a lactose-free formula (Nestle Nan ® free lactose) or lactose-containing milk formula (Nestle Nan 2 ® formula) after initial rehydration. Comparisons of stool frequency, duration of diarrhea and treatment failure rates were noted. Treatment fail- ure was defined as clinical requirement for intravenous infusion after rehydration or prolonged diarrhea (>7 days). Results The duration of diarrhea was similar between the two groups (P=0.195) in spite of two children who received lactose free formula did not resolve from diarrhea within 7 days of treat- ment. The median of stool frequency was indifferent in the two groups (P=0.199) in rotavirus gastroenteritis; there were no differ- ences in the duration of diarrhea or the stool frequency. Conclusion Children without dehydration or with mild dehydra- tion tolerated to lactose-containing formula as well as lactose-free formula for the treatment of acute diarrhea |
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| Item Description: | 0030-9311 2338-476X 10.14238/pi46.6.2006.271-5 |