Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation

• Main Authors: Emilio Llanos-González (Author), Francisco J. Sancho-Bielsa (Author), Javier Frontiñán-Rubio (Author), Yoana Rabanal-Ruíz (Author), Sonia García-Carpintero (Author), Eduardo Chicano (Author), Isabel Úbeda-Banon (Author), Alicia Flores-Cuadrado (Author), Lydia Giménez-Llort (Author), Francisco Javier Alcaín (Author), Juan Ramón Peinado (Author), Mario Durán-Prado (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite its robust proteopathic nature, the spatiotemporal signature of disrupted protein modules in sporadic Alzheimer's disease (AD) brains remains poorly understood. This considered oxidative stress contributes to AD progression and early intervention with coenzyme Q10 or its reduced form, u...