Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage

• Main Authors: Katrin Radloff (Author), Birgitt Gutbier (Author), Charlotte Maeve Dunne (Author), Hanieh Moradian (Author), Marko Schwestka (Author), Manfred Gossen (Author), Katharina Ahrens (Author), Laura Kneller (Author), Yadong Wang (Author), Akanksha Moga (Author), Leonidas Gkionis (Author), Oliver Keil (Author), Volker Fehring (Author), Daniel Tondera (Author), Klaus Giese (Author), Ansgar Santel (Author), Jörg Kaufmann (Author), Martin Witzenrath (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically modulate gene expression within ECs is of high therapeutic value in treating diseases such as those associated with lung edema. mRNAs formula...