N-type Calcium Channel Inhibition With Cilnidipine Elicits Glomerular Podocyte Protection Independent of Sympathetic Nerve Inhibition
We recently demonstrated that cilnidipine, an L/N-type calcium channel blocker, elicits protective effects against glomerular podocyte injury, in particular, in obese hypertensive rats that express the N-type calcium channel (N-CC). Since the N-CC is known to be expressed in sympathetic nerve ending...
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Elsevier,
2012-01-01T00:00:00Z.
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| 001 | doaj_5eced2ec8eee43b3b4e2364b35371dfb | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Bai Lei |e author |
| 700 | 1 | 0 | |a Daisuke Nakano |e author |
| 700 | 1 | 0 | |a Yoshihide Fujisawa |e author |
| 700 | 1 | 0 | |a Ya Liu |e author |
| 700 | 1 | 0 | |a Hirofumi Hitomi |e author |
| 700 | 1 | 0 | |a Hiroyuki Kobori |e author |
| 700 | 1 | 0 | |a Hirohito Mori |e author |
| 700 | 1 | 0 | |a Tsutomu Masaki |e author |
| 700 | 1 | 0 | |a Katsuhiko Asanuma |e author |
| 700 | 1 | 0 | |a Yasuhiko Tomino |e author |
| 700 | 1 | 0 | |a Akira Nishiyama |e author |
| 245 | 0 | 0 | |a N-type Calcium Channel Inhibition With Cilnidipine Elicits Glomerular Podocyte Protection Independent of Sympathetic Nerve Inhibition |
| 260 | |b Elsevier, |c 2012-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.12075FP | ||
| 520 | |a We recently demonstrated that cilnidipine, an L/N-type calcium channel blocker, elicits protective effects against glomerular podocyte injury, in particular, in obese hypertensive rats that express the N-type calcium channel (N-CC). Since the N-CC is known to be expressed in sympathetic nerve endings, we evaluated the reno-protective effects of cilnidipine in innervated and denervated spontaneously hypertensive rats (SHR). Male SHR were uninephrectomized and fed 4% high-salt diet (HS-UNX-SHR). Animals were divided into groups, as follows, and observed from 9 to 27 weeks of age: 1) vehicle (n = 14), 2) vehicle plus renal-denervation (n = 15), 3) cilnidipine (50 mg/kg per day, p.o.; n = 10), and 4) cilnidipine plus renal-denervation (n = 15). Renal denervation attenuated elevations in blood pressure, but failed to suppress urinary protein excretion and podocyte injury in HS-UNX-SHR. Cilnidipine in both innervated and denervated HS-UNX-SHR similarly induced significant antihypertensive effects, as well as suppressing the urinary protein excretion and podocyte injury, compared to vehicle-treated HS-UNX-SHR. These data indicate that renal nerves have a limited contribution to the cilnidipine-induced reno-protective effects in HS-UNX-SHR. Keywords:: cilnidipine, hypertension, N-type calcium channel, podocyte, renal sympathetic nerve | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 119, Iss 4, Pp 359-367 (2012) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319304803 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/5eced2ec8eee43b3b4e2364b35371dfb |z Connect to this object online. |