Multiple cutaneous melanomas associated with gastric and brain metastases

Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneo...

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Main Authors: Lara Caroline Grander (Author), Fernanda Cabral (Author), Alice Paixão Lisboa (Author), Gabrielle Vale (Author), Carlos Baptista Barcaui (Author), Juan Manuel Pineiro Maceira (Author)
Format: Book
Published: Sociedade Brasileira de Dermatologia, 2016-10-01T00:00:00Z.
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Summary:Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.
Item Description:0365-0596
10.1590/abd1806-4841.20164374