Multiple cutaneous melanomas associated with gastric and brain metastases

• Main Authors: Lara Caroline Grander (Author), Fernanda Cabral (Author), Alice Paixão Lisboa (Author), Gabrielle Vale (Author), Carlos Baptista Barcaui (Author), Juan Manuel Pineiro Maceira (Author)
• Format: Book
• Published: Sociedade Brasileira de Dermatologia, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0365-0596; 10.1590/abd1806-4841.20164374
• Keywords: Cyclin-dependent kinase inhibitor protein; Cyclin-dependent Kinases; Melanoma; Neoplasm metastasis; Dermatology; RL1-803
• Source: Anais Brasileiros de Dermatologia, Vol 91, Iss 5 suppl 1, Pp 98-100 (2016)

Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.