Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts' studies

• Main Authors: Didier Debieuvre (Author), Olivier Molinier (Author), Lionel Falchero (Author), Chrystèle Locher (Author), Dorine Templement-Grangerat (Author), Nicolas Meyer (Author), Hugues Morel (Author), Yannick Duval (Author), Bernard Asselain (Author), Alexia Letierce (Author), Jean Trédaniel (Author), Jean-Bernard Auliac (Author), Olivier Bylicki (Author), Lionel Moreau (Author), Mathieu Fore (Author), Romain Corre (Author), Sébastien Couraud (Author), Alexis Cortot (Author), Faraj Al Freijat (Author), Waad Al Sheikh (Author), Claire Alizon (Author), Karim Amrane (Author), Etienne Auvray (Author), Nicolae Banciu (Author), Alexandra Bedossa (Author), Issam Belhaj (Author), Antoine Belle (Author), Laure Belmont (Author), Kheir Eddine Benmammar (Author), Marie Bernardi (Author), Pascal Beynel (Author), Fréderic Bigot (Author), Acya Bizieux-Thaminy (Author), Anne-Sophie Bl (Author), Philippe Bonnefoy (Author), Soraya Bordier (Author), Anne-Sophie Bravard (Author), Éric Briens (Author), Philippe Brun (Author), Anne-Sophie Bugnet (Author), Laetitia Chablais (Author), Anne-Marie Chiappa (Author), Reda Chikouche (Author), François Christiann (Author), Caroline Clarot (Author), Joelle Courdeau-Labourie (Author), Jacky Crequit (Author), Charles Dayen (Author), Gonzague De chabot (Author), Chantal Decroisette (Author), Stéphanie Dehette (Author), Christian Delafosse (Author), Bertrand Delclaux (Author), Christina Delmas (Author), Pierre Demontrond (Author), Jean-Marc Dot (Author), Cécile Dujon (Author), Patrick Dumont (Author), Christine Dussopt (Author), Fatima Duval (Author), Fethi El Khanjari (Author), Kevin Fouet (Author), Hugues Francois (Author), Yannick Ghalloussi-Tebai (Author), Éric Goarant (Author), Benoît Godbert (Author), François Goupil (Author), Rym Haouachi (Author), Pierre-Alexandre Hauss (Author), Mohamad Jaafar (Author), Baihas Jarjour (Author), Serge Jeandeau (Author), Sylvie Julien (Author), Jean Philippe Kraemer (Author), Pierre Kuntz (Author), Florence Lamotte (Author), Sébastien Larive (Author), Thomas Laurent (Author), Hervé Le Floch (Author), Gwenaëlle Le Garff (Author), Jacques Le Treut (Author), Emmanuelle Lecuyer (Author), Christine Lefoll (Author), Olivier Leleu (Author), Marguerite Lepoulain Doubliez (Author), Virginie Levrat (Author), Sandrine Loutski-Vettese (Author), Edith Maetz (Author), Fanny Magne (Author), Cécile Maincent (Author), Alexa Mairovitz (Author), Catherine Marichy (Author), Nancy Marion (Author), David Marquette (Author), Bénédicte Martignac (Author), Stéphanie Martinez (Author), Clothilde Marty (Author), Philippe Masson (Author), Cyril Maurer (Author), Vincent Meniai (Author), Geoffroy Milliet De Faverges (Author), Isabelle Monnet (Author), Laurent Mosser (Author), Anne-Catherine Neidhardt (Author), David Nunes (Author), Julie Obert (Author), Vanessa Pante (Author), Magalie Paysse (Author), Herve Pegliasco (Author), Jean-Michel Peloni (Author), Christophe Perrin (Author), Lidia Petit (Author), Marjorie Picaud (Author), Julian Pinsolle (Author), Mihai Popa (Author), Laurent Portel (Author), Jean Quieffin (Author), Hong Rabut (Author), Élise Redureau (Author), David Renault (Author), Patrick Aldo Renault (Author), Claudia Rizzo (Author), Maud Russier (Author), Marielle Sabatini (Author), Thierry Saelens (Author), Sophie Schneider (Author), Philippe Slaouti (Author), Luc Stoven (Author), Vincent Tack (Author), Jean-Yves Tavernier (Author), Laurence Thirard (Author), Séverine Thomassin (Author), Marie Tiercin (Author), Jean Tredaniel (Author), Andreea Tudor (Author), Amélie Turlotte (Author), Colette Vincent (Author), Jérôme Virally (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2666-7762; 10.1016/j.lanepe.2022.100492
• Keywords: Lung cancer; Smoking habits; Real-life; Tumor characteristics; Adenocarcinoma; Non-small-cell lung cancer; Public aspects of medicine; RA1-1270
• Source: The Lancet Regional Health. Europe, Vol 22, Iss , Pp 100492- (2022)

Summary: Background: Long-term changes in lung cancer (LC) patients are difficult to evaluate. We report results from the French KBP-2020 real-life cohort. Methods: KBP-2020 was a prospective cohort that included all patients diagnosed with LC in 2020, in nonacademic public hospital in France. Patient and tumour characteristics were described and compared with similarly designed cohorts in 2000 and 2010. Findings: In 2020, 82 centers included 8,999 patients diagnosed with LC. The proportion of women increased: 34·6% (3114/8999) compared to, 24·3% (1711/7051) and 16·0% (904/5667) in 2010 and 2000 (p<0·0001). The proportion of non-smokers was higher in 2020 (12·6%, 1129/8983) than in previous cohorts (10·9% (762/7008) in 2010; 7·2% (402/5586) in 2000, p<0·0001). In 2020, at diagnosis, 57·6% (4405/7648) of patients had a metastatic/disseminated stage non-small-cell lung cancer (NSCLC) (58·3% (3522/6046) in 2010; 42·6% (1879/4411) in 2000, p<0·0001). Compared with 2000 and 2010 data, early survival improved slightly. In 2020, 3-month mortality of NSCLC varied from 3·0% [2·2 - 3·8] for localized to 9·6% [8·1 - 11·0] for locally advanced to 29·2% [27·8 - 30·6] for metastatic and was 24·8% [22·3 - 27·3] for SCLC. Interpretation: To our knowledge KBP cohorts have been the largest, prospective, real-world cohort studies involving LC patients conducted in worldwide. The trend found in our study shows an increase in LC in women and still a large proportion of patients diagnosed at metastatic or disseminated stage. Funding: The study was promoted by the French College of General Hospital Pulmonologists with financial support of industrials laboratories.