Regulation of sirtuin function by posttranslational modifications
Sirtuins are homologs of the yeast silencing information regulator 2 (Sir2) protein, an NAD+-dependent (histone) deacetylase. In mammals 7 different sirtuins, SIRT1-7, have been identified, which share a common catalytic core domain but possess distinct N- and C-terminal extensions. This core domain...
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Frontiers Media S.A.,
2012-02-01T00:00:00Z.
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