Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling

• Main Authors: Jia-Ying Wu (Author), Ying-Jie Chen (Author), Xiu-Qiong Fu (Author), Jun-Kui Li (Author), Ji-Yao Chou (Author), Cheng-Le Yin (Author), Jing-Xuan Bai (Author), Ying Wu (Author), Xiao-Qi Wang (Author), Amy Sze-man Li (Author), Lut Yi Wong (Author), Zhi-Ling Yu (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibroblast-like synoviocytes (FLS) have cancer cell-like characteristics, such as abnormal proliferation and resistance to apoptosis, and play a pathogenic role in rheumatoid arthritis (RA). Hyperproliferation of RA-FLS that can be triggered by the activation of interleukin-6/sig...