Exploring the interaction between epidermal growth factor receptor tyrosine kinase and some of the synthesized inhibitors using combination of in-silico and in-vitro cytotoxicity methods

• Main Authors: Rezvan Rezaee Nasab (Author), Mahboubeh Mansourian (Author), Farshid Hassanzadeh (Author), Mohsen Shahlaei (Author)
• 格式: 圖書
• 出版: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Quinazoline derivatives are potent inhibitors of human epidermal growth factor receptor (EGFR) as anticancer agents. In this study, the cytotoxic effects of a new series of synthesized quinazoline derivatives were evaluated using MTT assay against MCF-7 and HT-29 cell lines. Using molecular docking,...