Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol

• Main Authors: Xiangmeng Wu (Author), Qinghao Zhang (Author), Jiamei Guo (Author), Yufei Jia (Author), Ziqian Zhang (Author), Manman Zhao (Author), Yakun Yang (Author), Baolian Wang (Author), Jinping Hu (Author), Li Sheng (Author), Yan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

10-Chloromethyl-11-demethyl-12-oxo-calanolide (F18), an analog of calanolide A, is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1. Here, we report the metabolic profile and the results of associated biochemical studies of F18 in vitro and in vivo. The metabolites of F18 w...