The Application of Global Sensitivity Analysis in the Development of a Physiologically Based Pharmacokinetic Model for m-Xylene and Ethanol Co-Exposure in Humans
Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in humans. SA was used to identify those parameters which had the most significant impact on variab...
Saved in:
Main Authors: | George D Loizou (Author), Kevin eMcNally (Author), Kate eJones (Author), John eCocker (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2015-06-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
A probabilistic model of human variability in physiology for future application to dose reconstruction and QIVIVE
by: Kevin eMcNally, et al.
Published: (2015) -
A Workflow for Global Sensitivity Analysis of PBPK Models
by: Kevin eMcNally, et al.
Published: (2011) -
Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system
by: Annie eLumen, et al.
Published: (2015) -
Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data
by: Kevin McNally, et al.
Published: (2019) -
MEGen: A Physiologically Based Pharmacokinetic Model Generator
by: George D Loizou, et al.
Published: (2011)