PEG-Functionalized Magnetite Nanoparticles for Modulation of Microbial Biofilms on Voice Prosthesis

• Autori principali: Mara Caciandone (Autore), Adelina-Gabriela Niculescu (Autore), Aurelian Radu Roșu (Autore), Valentina Grumezescu (Autore), Irina Negut (Autore), Alina Maria Holban (Autore), Ovidiu Oprea (Autore), Bogdan Ștefan Vasile (Autore), Alexandra Cătălina Bîrcă (Autore), Alexandru Mihai Grumezescu (Autore), Miruna Silvia Stan (Autore), Alina Georgiana Anghel (Autore), Ion Anghel (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Riassunto

This study reports the fabrication of nanostructured coatings based on magnetite, polyethyleneglycol, and biologically active molecule (polymyxin B-PM) for producing biofilm-resistant surfaces (voice prosthesis). Magnetite nanoparticles (MNPs) have been synthesized and functionalized using a co-precipitation method and were further deposited into thin coatings using the matrix-assisted pulsed laser evaporation (MAPLE) technique. The obtained nanoparticles and coatings were characterized by X-ray diffraction (XRD), thermogravimetric analysis with differential scanning calorimetry (TGA-DSC), scanning electron microscopy (SEM), transmission electron microscopy with selected area electron diffraction (TEM-SAED), Fourier-transform infrared spectroscopy (FT-IR), and infrared microscopy (IRM). Their antibiofilm activity was tested against relevant <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> bacterial strains. The Fe₃O₄@PEG/PM surface of modified voice prosthesis sections reduced the number of CFU/mL up to four orders of magnitude in the case of <i>S. aureus</i> biofilm. A more significant inhibitory effect is noticed in the case of <i>P. aeruginosa</i> up to five folds. These results highlight the importance of new Fe₃O₄@PEG/PM in the biomedical field.

Descrizione del documento

10.3390/antibiotics11010039
2079-6382