QT PRODACT: Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles

• Main Authors: Yoshihide Kii (Author), Seiji Hayashi (Author), Mitsuyasu Tabo (Author), Takashi Shimosato (Author), Hitoshi Fukuda (Author), Tetsuji Itoh (Author), Hideto Amano (Author), Mamoru Saito (Author), Hajime Morimoto (Author), Kiyoshi Yamada (Author), Atsuhiro Kanda (Author), Toshimasa Ishitsuka (Author), Takanobu Yamazaki (Author), Yoichi Kiuchi (Author), Shinya Taniguchi (Author), Tatsuya Mori (Author), Shigekazu Shimizu (Author), Yuji Tsurubuchi (Author), Shun-ichi Yasuda (Author), Shin-ichi Kitani (Author), Chiaki Shimada (Author), Kazuo Kobayashi (Author), Masaharu Komeno (Author), Chieko Kasai (Author), Toshiyasu Hombo (Author), Keiji Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene (hERG) currents. In this study using isolated guin...