Vitamin D Deficiency and Maternal Diseases as Risk Factors for the Development of Macrosomia in Newborns

• Main Authors: Nazym Ailbayeva (Author), Aliya Alimbayeva (Author), Oxana Yurkovskaya (Author), Raida Faizova (Author), Sayat Tanatarov (Author), Gulnara Taiorazova (Author), Aizhan Abylgazinova (Author), Andrey Orekhov (Author), Ulzhan Jamedinova (Author), Lyudmila Pivina (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3390/children11101160; 2227-9067
• Keywords: macrosomia; newborns; vitamin D; maternal obesity; maternal hypothyroidism; risk factors; Pediatrics; RJ1-570
• Source: Children, Vol 11, Iss 10, p 1160 (2024)

<i>Background:</i> The aim is to assess the association between the level of vitamin D, maternal diseases, and macrosomia in newborns. <i>Methods</i>: This study included 258 full-term newborns (86 newborns with macrosomia; and 172 newborns with normal weight). Enzyme immunoassays for the determination of vitamin D were performed. <i>Results:</i> Newborns with macrosomia were statistically significantly more likely to have severe vitamin D deficiency compared with control (13.5 ± 6.7 ng/mL vs. 21.3 ± 12.1 ng/mL; <i>p</i> < 0.05). In the main group, severe deficiency was found in 40.7% of newborns, in the control group this rate was 5.8% (χ² = 71,788, df = 3, <i>p</i> < 0.001). Multiple regression analysis shows that statistically significant risk factors for the development of macrosomia were vitamin D deficiency in the cord blood (OR = 2.29), maternal age over 36 years old (OR = 19.54), and hypothyroidism (OR = 9.35). <i>Conclusion:</i> the results of our study demonstrate relationship between macrosomia in newborns and vitamin D deficiency in the cord blood, maternal overweight and obesity, maternal age and thyroid disease.