Mesoporous silica and alumina nanoparticles to improve drug delivery of pioglitazone on diabetic type 1 nephropathy in rats

Background and purpose: Diabetic nephropathy leads to end-stage renal disease. The present study aimed to evaluate the prophylactic effect of pioglitazone-loaded mesoporous silica and alumina scaffold on renal function and the underlying mechanisms in streptozotocin-induced diabetic rats. Experiment...

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Main Authors: Jaleh Varshosaz (Author), Saeedeh Ahmadipour (Author), Armin Dezhangfard (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2024-08-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Jaleh Varshosaz  |e author 
700 1 0 |a Saeedeh Ahmadipour  |e author 
700 1 0 |a Armin Dezhangfard  |e author 
245 0 0 |a Mesoporous silica and alumina nanoparticles to improve drug delivery of pioglitazone on diabetic type 1 nephropathy in rats 
260 |b Wolters Kluwer Medknow Publications,   |c 2024-08-01T00:00:00Z. 
500 |a 1735-5362 
500 |a 1735-9414 
500 |a 10.4103/RPS.RPS_65_23 
520 |a Background and purpose: Diabetic nephropathy leads to end-stage renal disease. The present study aimed to evaluate the prophylactic effect of pioglitazone-loaded mesoporous silica and alumina scaffold on renal function and the underlying mechanisms in streptozotocin-induced diabetic rats. Experimental approach: The mesoporous nanoparticles were synthesized by chemical methods from tetraethylorthosilicate and aluminum isopropoxide and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The soaking method was applied to load pioglitazone into the mesoporous silica and alumina. Subsequently, the most capable formulation was evaluated for lipid profile, blood glucose, renal function biomarkers, malondialdehyde, and kidney histopathological changes in diabetic rats. Findings/Results: Pioglitazone loaded in the mesoporous included a superior release of about 80%. No interaction was observed in Fourier transform infrared spectroscopy and X-ray diffraction was shown crystalline. Scanning electron microscopy showed the size of the nanometer in the range of 100 - 300 nm. Mesoporous silica containing the drug significantly decreased urinary parameters, triglycerides, low-density lipoprotein, blood urea nitrogen, blood glucose, malondialdehyde, and creatinine. In addition, it showed increased high-density lipoprotein, significantly. The renal histopathological changes indicated improvement compared with the untreated diabetic group. Conclusion and implications: It was concluded that the mesoporous was potent to serve as a promising drug carrier and a platform aimed at the delivery of poorly water-soluble drugs for improving oral bioavailability. Furthermore, it has the potential to provide a beneficial effect on the changes in diabetic parameters. 
546 |a EN 
690 |a diabetic nephropathy 
690 |a mesoporous alumina 
690 |a mesoporous silica 
690 |a pioglitazone 
690 |a poorly water-soluble 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Research in Pharmaceutical Sciences, Vol 19, Iss 4, Pp 459-474 (2024) 
787 0 |n https://journals.lww.com/10.4103/RPS.RPS_65_23 
787 0 |n https://doaj.org/toc/1735-5362 
787 0 |n https://doaj.org/toc/1735-9414 
856 4 1 |u https://doaj.org/article/61382e13d4e84c55a2bf976d69d6737c  |z Connect to this object online.