Donepezil: A cause of inadequate muscle relaxation and delayed neuromuscular recovery
A 74-year-old female with diabetes mellitus type II and Alzheimer's disease, taking donepezil for 4 months was operated for right modified radical mastectomy under general anesthesia. During the procedure a higher dose of non-depolarizing muscle relaxant was required than those recommended for...
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| Format: | Book |
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Wolters Kluwer Medknow Publications,
2011-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_618f0d85ed9d4a35aa370e7706232e59 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Alka Bhardwaj |e author |
| 700 | 1 | 0 | |a Sudhindra Dharmavaram |e author |
| 700 | 1 | 0 | |a Sonia Wadhawan |e author |
| 700 | 1 | 0 | |a Anjali Sethi |e author |
| 700 | 1 | 0 | |a Poonam Bhadoria |e author |
| 245 | 0 | 0 | |a Donepezil: A cause of inadequate muscle relaxation and delayed neuromuscular recovery |
| 260 | |b Wolters Kluwer Medknow Publications, |c 2011-01-01T00:00:00Z. | ||
| 500 | |a 0970-9185 | ||
| 500 | |a 10.4103/0970-9185.81833 | ||
| 520 | |a A 74-year-old female with diabetes mellitus type II and Alzheimer's disease, taking donepezil for 4 months was operated for right modified radical mastectomy under general anesthesia. During the procedure a higher dose of non-depolarizing muscle relaxant was required than those recommended for her age yet the muscle relaxation was inadequate intra-operatively. Residual neuromuscular blockade persisted postoperatively, due to the cumulative effect of large doses of non-depolarizing muscle relaxant, needing post-operative ventilatory assistance. After ruling out other causes of resistance to non-depolarizing muscle relaxants, we concluded that acetylcholinesterase inhibitor donepezil was primarily responsible for inadequate muscle relaxation and delayed post-operative neuromuscular recovery. | ||
| 546 | |a EN | ||
| 690 | |a Alzheimer's disease | ||
| 690 | |a donepezil | ||
| 690 | |a delayed neuromuscular recovery general anaesthesia | ||
| 690 | |a Geriatric | ||
| 690 | |a non depolarizing muscle relaxant | ||
| 690 | |a Anesthesiology | ||
| 690 | |a RD78.3-87.3 | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Anaesthesiology Clinical Pharmacology, Vol 27, Iss 2, Pp 247-248 (2011) | |
| 787 | 0 | |n http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=2;spage=247;epage=248;aulast=Bhardwaj | |
| 787 | 0 | |n https://doaj.org/toc/0970-9185 | |
| 856 | 4 | 1 | |u https://doaj.org/article/618f0d85ed9d4a35aa370e7706232e59 |z Connect to this object online. |