Oral Squamous Cell Carcinomas and Expression of Inflammatory Markers

• Main Authors: Ruth Tramontani Ramos (Author), Karla Malta Ferreira (Author), Lucio Souza Gonçalves (Author), Luciana Armada (Author), André Luiz da Rocha Azevedo (Author), Teresa Cristina Ribeiro Bartholomeu dos Santos (Author), Mayra Stambovsky Vieira (Author), Alexandre Marques Paes Silva (Author), Dennis de Carvalho Ferreira (Author), Marcia Gonçalves Ribeiro (Author)
• Format: Book
• Published: Editorial Ciencias Médicas, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Objectives: To describe the clinical and histopathological information of oral squamous cell carcinomas an oral pathology clinic of a private university in Rio de Janeiro state, Brazil (1998−2017) and to evaluate the immunoexpression of some inflammatory markers (nterferon-gamma, cluster of differentiation 57, and cluster of differentiation 68). Methods: Clinical data were collected and histopathological evaluations of 183 oral squamous cell carcinomas were performed at an oral pathology clinic of a private university in Rio de Janeiro state, Brazil (1998−2017). Twenty-two paraffin blocks underwent immunohistochemistry to measure the Interferon-gamma, cluster of differentiation 57, and cluster of differentiation 68 expressions and positivity, and were classified as negative/focal, weak/moderate, or strong. Results: Thereabout 81% of the sample were male and 57% Caucasian. The average age was 58.6 years. Tongue cancers were the most prevalent (36.6%) and 48.1% had a moderately differentiated oral squamous cell carcinomas. Interferon-gamma was expressed in all cases, and 91% had the maximum degree of marking. The cluster of differentiation 68 expression had a maximum degree in 41% of the tumours, and surprisingly all of them in concomitance with the maximum Interferon-gamma-markings. cluster of differentiation 57 was strongly expressed in 45.5% of the sample. Conclusion: Oral squamous cell carcinomas was more frequent in Caucasians, in their fifth decade of life, and located on the tongue. The Interferon-gamma expression was observed in all cases, its role in the development of tumours and the concomitant expression of cluster of differentiation 68 suggests a possible differentiation for the M2 phenotype of tumours and a consequently a poor prognosis.

Item Description

0034-7507
1561-297X