Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

• Main Authors: Yujun Zhou (Author), Jingshu Tang (Author), Jiaqi Lan (Author), Yong Zhang (Author), Hongyue Wang (Author), Qiuyu Chen (Author), Yuying Kang (Author), Yang Sun (Author), Xinhong Feng (Author), Lei Wu (Author), Hongtao Jin (Author), Shizhong Chen (Author), Ying Peng (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple pathological mechanisms are considered to contribute to the progression of ALS, including neuronal oxidative stress and mitochond...