Should a single blastocyst transfer policy be a clinical decision or should it depend on the embryological evaluation on day 3?
<p>Abstract</p> <p>Background</p> <p>Single blastocyst transfer has the advantage of maximizing the fresh single pregnancy rate. However, in patients with a low number of good quality embryos on day 3, it remains unclear whether immediate embryo transfer or further embr...
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2011-05-01T00:00:00Z.
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| 001 | doaj_61d661f778c94e97838647e00d854e5c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Verheyen Greta |e author |
| 700 | 1 | 0 | |a Camus Michel |e author |
| 700 | 1 | 0 | |a Van den Abbeel Etienne |e author |
| 700 | 1 | 0 | |a Van Landuyt Lisbet |e author |
| 700 | 1 | 0 | |a Stoop Dominic |e author |
| 700 | 1 | 0 | |a Devroey Paul |e author |
| 245 | 0 | 0 | |a Should a single blastocyst transfer policy be a clinical decision or should it depend on the embryological evaluation on day 3? |
| 260 | |b BMC, |c 2011-05-01T00:00:00Z. | ||
| 500 | |a 10.1186/1477-7827-9-60 | ||
| 500 | |a 1477-7827 | ||
| 520 | |a <p>Abstract</p> <p>Background</p> <p>Single blastocyst transfer has the advantage of maximizing the fresh single pregnancy rate. However, in patients with a low number of good quality embryos on day 3, it remains unclear whether immediate embryo transfer or further embryo culture with blastocyst transfer is the most preferable option.</p> <p>Methods</p> <p>A retrospective cohort study was carried out in which the outcome of 590 fresh in vitro fertilization (IVF) cycles over a 15 months period and their cryo cycles were analyzed. A total of 341 patients cycles had an elective day 5 strategy independent of intermediate embryo evaluation while another 249 patients underwent a day 5 embryo transfer only if at least four embryos were available on day 3. Blastocyst vitrification was performed using a closed high security system.</p> <p>Results</p> <p>Demographics, stimulation parameters and embryological data were comparable in the two groups. Patients in the elective day 5 group had a lower fresh transfer rate (90.62% vs. 95.18%, p < 0.05) as compared to patients with a day 3 or day 5 embryo transfer policy. No difference was observed in the fresh live birth rate and multiple pregnancy rate per initiated cycle (32.84% vs. 28.92%; 1.17% vs 0%) The projected cumulative ongoing pregnancy rate compensating for double counting in case subjects have more than one pregnancy is not different (42.58% vs. 39.84%).</p> <p>Conclusions</p> <p>Despite lower fresh transfer rates, elective single blastocyst transfer yields a similar projected cumulative ongoing pregnancy rate as in a policy with cleavage stage or blastocyst transfer depending on a good quality embryo count on day 3.</p> | ||
| 546 | |a EN | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 690 | |a Reproduction | ||
| 690 | |a QH471-489 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Reproductive Biology and Endocrinology, Vol 9, Iss 1, p 60 (2011) | |
| 787 | 0 | |n http://www.rbej.com/content/9/1/60 | |
| 787 | 0 | |n https://doaj.org/toc/1477-7827 | |
| 856 | 4 | 1 | |u https://doaj.org/article/61d661f778c94e97838647e00d854e5c |z Connect to this object online. |