4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages

• Autors principals: Thai Hien Tu (Autor), Chu-Sook Kim (Autor), Tsuyoshi Goto (Autor), Teruo Kawada (Autor), Byung-Sam Kim (Autor), Rina Yu (Autor)
• Format: Llibre
• Publicat: Hindawi Limited, 2012-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Obesity-induced adipose inflammation is characterized by recruitment of macrophages to adipose tissue and release of inflammatory cytokines. 4-1BB, a costimulatory receptor, modulates inflammatory processes through interaction with its ligand 4-1BBL on immune cell surfaces. In this study, we examine...