Population pharmacokinetics of letermovir following oral and intravenous administration in healthy participants and allogeneic hematopoietic cell transplantation recipients

• Main Authors: Marita Prohn (Author), Anders Viberg (Author), Da Zhang (Author), Kevin Dykstra (Author), Casey Davis (Author), Sreeraj Macha (Author), Philip Sabato (Author), Dinesh deAlwis (Author), Marian Iwamoto (Author), Craig Fancourt (Author), Carolyn R. Cho (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Letermovir is indicated for prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Two‐stage population pharmacokinetic (PK) modeling of letermovir was conducted to support dose rationale and evaluate the impact of intrinsic/...