Evaluation of the Role of C-Reactive Protein in Salivary Gland Disease: A Clinical Study

• Main Authors: Batchu Pavan Kumar (Author), Vidya Devi (Author), Vishnu Gowtam (Author), P Manoj (Author), Riddhi Chawla (Author), Sheetal Mujoo (Author), Neshaneni Satish Kumar (Author), Trupti G Makwana (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0976-4879; 0975-7406; 10.4103/jpbs.jpbs_383_24
• Keywords: biomarker; c-reactive protein; inflammation; salivary gland illness; tertiary care; Pharmacy and materia medica; RS1-441; Analytical chemistry; QD71-142
• Source: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss Suppl 3, Pp S2764-S2766 (2024)

Objectives: The purpose of this study was to assess, in a tertiary care context, the significance of C-reactive protein (CRP) in salivary gland illness. Methods: This prospective research included 100 consecutive individuals with symptoms indicative of illness of the salivary glands. Demographic information, clinical information, and presenting symptoms were noted. Studies on salivary gland imaging were conducted, and a high-sensitivity test was used to quantify CRP levels. Radiology and clinical data were used to classify the disease's severity. The relationship between CRP levels and illness severity was examined using statistical methods such as regression analysis and correlation testing. Findings: There was a strong correlation between the severity of salivary gland illness and elevated CRP levels. There was a statistically significant correlation (P < 0.05) between high CRP levels and the severity of salivary gland disease. When compared to patients with mild or moderate illness, patients with severe disease had greater CRP levels. In all severity groups, pain was the most common presenting symptom, followed by swelling and trouble swallowing. The variable character of disorders affecting the salivary glands was highlighted by the considerable variation in symptom distribution according to disease severity. Conclusion: In conclusion, current research points to CRP as a possible biomarker for determining the degree of illness in conditions affecting the salivary glands. Elevated CRP levels have been linked to severe illness, which suggests that CRP may be useful in risk assessment and therapy selection. To confirm these results and investigate the therapeutic applications of CRP-guided treatment in salivary gland disorders, more investigation is necessary.