Naringin is a promising natural compound for therapy of iron-overload disorders
Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for t...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Book |
| Published: |
Universidade de São Paulo,
2022-07-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_62f63b8b02bf4a958e534e10f7c851d4 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mehrdad Jahanshahi |e author |
| 700 | 1 | 0 | |a Masoumeh Khalili |e author |
| 700 | 1 | 0 | |a Asra Margdari |e author |
| 700 | 1 | 0 | |a Mahdi Aalikhani |e author |
| 245 | 0 | 0 | |a Naringin is a promising natural compound for therapy of iron-overload disorders |
| 260 | |b Universidade de São Paulo, |c 2022-07-01T00:00:00Z. | ||
| 500 | |a 2175-9790 | ||
| 500 | |a 10.1590/s2175-97902022e19409 | ||
| 520 | |a Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl's staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders. | ||
| 546 | |a EN | ||
| 690 | |a Iron chelation activity | ||
| 690 | |a Naringin | ||
| 690 | |a Deferoxamine | ||
| 690 | |a Iron overloaded mice | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Brazilian Journal of Pharmaceutical Sciences, Vol 58 (2022) | |
| 787 | 0 | |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100622&tlng=en | |
| 787 | 0 | |n https://doaj.org/toc/2175-9790 | |
| 856 | 4 | 1 | |u https://doaj.org/article/62f63b8b02bf4a958e534e10f7c851d4 |z Connect to this object online. |