The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication.

• Автори: Xiao-Dan Li (Автор), Chao Shan (Автор), Cheng-Lin Deng (Автор), Han-Qing Ye (Автор), Pei-Yong Shi (Автор), Zhi-Ming Yuan (Автор), Peng Gong (Автор), Bo Zhang (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...