A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal

• Main Authors: Qiu Tu (Author), Dong Yang (Author), Xianning Zhang (Author), Xintong Jia (Author), Sanqi An (Author), Lanzhen Yan (Author), Hongjuan Dai (Author), Yuhua Ma (Author), Chengwei Tang (Author), Weimin Tong (Author), Zongliu Hou (Author), Longbao Lv (Author), Jing Tan (Author), Xudong Zhao (Author)
• Format: Book
• Published: The Company of Biologists, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer is one of the most lethal common cancers. The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial, and recent evidence suggested acinar cells as the most probable candidate. However, the genetic alterations driving the transformation of pancreatic acina...