Preparation, Characterization and Evaluation Biological Activity of Cobalt (II) with Mixed Ligands complexes
New cobalt (II) complexes with mixed ligands including [(2- oxime-4-hydrazone) pentane (L<sub>1</sub>H) and 2-chlorobenzaldehyde thiosemicarbazone(T<sub>1</sub>H) ,or 3,4-dimethoxy acetophenone thiosemicarbazone (T<sub>2</sub>H); glycine (GH) or metformin (mf)] ha...
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| Main Authors: | , |
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| Format: | Book |
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College of Education for Pure Sciences,
2021-06-01T00:00:00Z.
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| Summary: | New cobalt (II) complexes with mixed ligands including [(2- oxime-4-hydrazone) pentane (L<sub>1</sub>H) and 2-chlorobenzaldehyde thiosemicarbazone(T<sub>1</sub>H) ,or 3,4-dimethoxy acetophenone thiosemicarbazone (T<sub>2</sub>H); glycine (GH) or metformin (mf)] have been prepared in both pH (6.5-7) and (9.5-10) using classical and microwave techniques. The resulting complexes have been characterized using physio- chemical and spectral techniques. The study suggested that the complexes have the generalformulate [Co(L<sub>1</sub>H)(TH)(BH)](CH<sub>3</sub>COO)<sub>2</sub>and[Co(L<sub>1</sub>)(TH)(G)]or[Co(L<sub>1</sub>)(T)(mf)] at pH (6.5-7) and (9.5- 10), respectively {where TH= T<sub>1</sub>H or T<sub>2</sub>H; T= deprotonated T<sub>1</sub>H or T<sub>2</sub>H; L<sub>1</sub>H=L<sub>1</sub>=deprotenated; BH= GH or mf; G= deprotonated GH]. Hexacoordinated mononuclear complexes having distorted octahedral geometries have been investigated. The biologicall activity of the ligands and complexes have been evaluated by agar plate diffusion technique against <em>Echerichia coli, Klipsila pnnemoia, Staphylococcus aureus and Pseudomonas aeruginosa</em>. Some compounds have been found to have antibacterial activity. |
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| Item Description: | 1812-125X 2664-2530 10.33899/edusj.2020.128321.1110 |