mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy

• Váldodahkkit: Kosuke Sasaki (Dahkki), Yusuke Sato (Dahkki), Kento Okuda (Dahkki), Kazuki Iwakawa (Dahkki), Hideyoshi Harashima (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Dendritic cells (DCs) are attractive antigen-presenting cells to be targeted for vaccinations. However, the systemic delivery of mRNA to DCs is hampered by technical challenges. We recently reported that it is possible to regulate the size of RNA-loaded lipid nanoparticles (LNPs) to over 200 nm with...