Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy

• Main Authors: Joshua C. Peterson (Author), Lambertus J. Wisse (Author), Valerie Wirokromo (Author), Tessa van Herwaarden (Author), Anke M. Smits (Author), Adriana C. Gittenberger-de Groot (Author), Marie-José T. H. Goumans (Author), J. Conny VanMunsteren (Author), Monique R. M. Jongbloed (Author), Marco C. DeRuiter (Author)
• Format: Book
• Published: The Company of Biologists, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The mechanisms underlying BAV-associated aortopathy are poorly understood. This study examined BAV-associated aort...