Soluble Tumor Necrosis Factor Receptor 1 is Associated With Cardiovascular Risk in Persons With Coronary Artery Calcium Score of Zero
Background: A coronary artery calcium (CAC) score of zero confers a low but nonzero risk of atherosclerotic cardiovascular events (CVD) in asymptomatic patient populations, and additional risk stratification is needed to guide preventive interventions. Soluble tumor necrosis factor receptors (sTNFR-...
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Case Western Reserve University,
2021-12-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_63a47b98cbce4ab4a0b03a5076e24d6a | ||
042 | |a dc | ||
100 | 1 | 0 | |a Tony Dong |e author |
700 | 1 | 0 | |a Graham Bevan |e author |
700 | 1 | 0 | |a David Zidar |e author |
700 | 1 | 0 | |a Miguel Cainzos Achirica |e author |
700 | 1 | 0 | |a Khurram Nasir |e author |
700 | 1 | 0 | |a Imran Rashid |e author |
700 | 1 | 0 | |a Sanjay Rajagopalan |e author |
700 | 1 | 0 | |a Sadeer Al-Kindi |e author |
245 | 0 | 0 | |a Soluble Tumor Necrosis Factor Receptor 1 is Associated With Cardiovascular Risk in Persons With Coronary Artery Calcium Score of Zero |
260 | |b Case Western Reserve University, |c 2021-12-01T00:00:00Z. | ||
500 | |a 10.20411/pai.v6i2.477 | ||
500 | |a 2469-2964 | ||
520 | |a Background: A coronary artery calcium (CAC) score of zero confers a low but nonzero risk of atherosclerotic cardiovascular events (CVD) in asymptomatic patient populations, and additional risk stratification is needed to guide preventive interventions. Soluble tumor necrosis factor receptors (sTNFR-1 and sTNFR-2) are shed in the context of TNF-alpha signaling and systemic inflammation, which play a role in atherosclerosis and plaque instability. We hypothesized that serum sTNFR-1 concentrations may aid in cardiovascular risk stratification among asymptomatic patients with a CAC score of zero. Methods: We included all participants with CAC=0 and baseline sTNFR-1 measurements from the prospective cohort Multi-Ethnic Study of Atherosclerosis (MESA). The primary outcome was a composite CVD event (myocardial infarction, stroke, coronary revascularization, cardiovascular death). Results: The study included 1471 participants (mean age 57.6 years, 64% female), with measured baseline sTNFR-1 ranging from 603 pg/mL to 5544 pg/mL (mean 1294 pg/mL ±378.8 pg/mL). Over a median follow-up of 8.5 years, 37 participants (2.5%) experienced a CVD event. In multivariable analyses adjusted for Framingham Score, doubling of sTNFR-1 was associated with a 3-fold increase in the hazards of CVD (HR 3.0, 95% CI: 1.48- 6.09, P = 0.002), which remained significant after adjusting for traditional CVD risk factors individually (HR 2.29; 95% CI: 1.04-5.06, P=0.04). Doubling of sTNFR-1 was also associated with progression of CAC >100, adjusted for age (OR 2.84, 95% CI: 1.33-6.03, P=0.007). Conclusions: sTNFR-1 concentrations are associated with more CVD events in participants with a CAC score of zero. Utilizing sTNFR-1 measurements may improve cardiovascular risk stratification and guide primary prevention in otherwise low-risk individuals. | ||
546 | |a EN | ||
690 | |a soluble tumor necrosis factor receptor; | ||
690 | |a TNF alpha; | ||
690 | |a coronary calcium score; | ||
690 | |a cardiovascular risk stratification; | ||
690 | |a MESA | ||
690 | |a Pathology | ||
690 | |a RB1-214 | ||
690 | |a Immunologic diseases. Allergy | ||
690 | |a RC581-607 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Pathogens and Immunity, Vol 6, Iss 2 (2021) | |
787 | 0 | |n https://www.paijournal.com/index.php/paijournal/article/view/477 | |
787 | 0 | |n https://doaj.org/toc/2469-2964 | |
856 | 4 | 1 | |u https://doaj.org/article/63a47b98cbce4ab4a0b03a5076e24d6a |z Connect to this object online. |