Soluble Tumor Necrosis Factor Receptor 1 is Associated With Cardiovascular Risk in Persons With Coronary Artery Calcium Score of Zero

Background: A coronary artery calcium (CAC) score of zero confers a low but nonzero risk of atherosclerotic cardiovascular events (CVD) in asymptomatic patient populations, and additional risk stratification is needed to guide preventive interventions. Soluble tumor necrosis factor receptors (sTNFR-...

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Main Authors: Tony Dong (Author), Graham Bevan (Author), David Zidar (Author), Miguel Cainzos Achirica (Author), Khurram Nasir (Author), Imran Rashid (Author), Sanjay Rajagopalan (Author), Sadeer Al-Kindi (Author)
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Published: Case Western Reserve University, 2021-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Tony Dong  |e author 
700 1 0 |a Graham Bevan  |e author 
700 1 0 |a David Zidar  |e author 
700 1 0 |a Miguel Cainzos Achirica  |e author 
700 1 0 |a Khurram Nasir  |e author 
700 1 0 |a Imran Rashid  |e author 
700 1 0 |a Sanjay Rajagopalan  |e author 
700 1 0 |a Sadeer Al-Kindi  |e author 
245 0 0 |a Soluble Tumor Necrosis Factor Receptor 1 is Associated With Cardiovascular Risk in Persons With Coronary Artery Calcium Score of Zero 
260 |b Case Western Reserve University,   |c 2021-12-01T00:00:00Z. 
500 |a 10.20411/pai.v6i2.477 
500 |a 2469-2964 
520 |a Background: A coronary artery calcium (CAC) score of zero confers a low but nonzero risk of atherosclerotic cardiovascular events (CVD) in asymptomatic patient populations, and additional risk stratification is needed to guide preventive interventions. Soluble tumor necrosis factor receptors (sTNFR-1 and sTNFR-2) are shed in the context of TNF-alpha signaling and systemic inflammation, which play a role in atherosclerosis and plaque instability. We hypothesized that serum sTNFR-1 concentrations may aid in cardiovascular risk stratification among asymptomatic patients with a CAC score of zero.  Methods: We included all participants with CAC=0 and baseline sTNFR-1 measurements from the prospective cohort Multi-Ethnic Study of Atherosclerosis (MESA). The primary outcome was a composite CVD event (myocardial infarction, stroke, coronary revascularization, cardiovascular death).  Results: The study included 1471 participants (mean age 57.6 years, 64% female), with measured baseline sTNFR-1 ranging from 603 pg/mL to 5544 pg/mL (mean 1294 pg/mL ±378.8 pg/mL). Over a median follow-up of 8.5 years, 37 participants (2.5%) experienced a CVD event. In multivariable analyses adjusted for Framingham Score, doubling of sTNFR-1 was associated with a 3-fold increase in the hazards of CVD (HR 3.0, 95% CI: 1.48- 6.09, P = 0.002), which remained significant after adjusting for traditional CVD risk factors individually (HR 2.29; 95% CI: 1.04-5.06, P=0.04). Doubling of sTNFR-1 was also associated with progression of CAC >100, adjusted for age (OR 2.84, 95% CI: 1.33-6.03, P=0.007).  Conclusions: sTNFR-1 concentrations are associated with more CVD events in participants with a CAC score of zero. Utilizing sTNFR-1 measurements may improve cardiovascular risk stratification and guide primary prevention in otherwise low-risk individuals.  
546 |a EN 
690 |a soluble tumor necrosis factor receptor; 
690 |a TNF alpha; 
690 |a coronary calcium score;  
690 |a cardiovascular risk stratification; 
690 |a MESA 
690 |a Pathology 
690 |a RB1-214 
690 |a Immunologic diseases. Allergy 
690 |a RC581-607 
655 7 |a article  |2 local 
786 0 |n Pathogens and Immunity, Vol 6, Iss 2 (2021) 
787 0 |n https://www.paijournal.com/index.php/paijournal/article/view/477 
787 0 |n https://doaj.org/toc/2469-2964 
856 4 1 |u https://doaj.org/article/63a47b98cbce4ab4a0b03a5076e24d6a  |z Connect to this object online.