Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma
Abstract Background Osteosarcoma is a malignant tumor of bone and soft tissue in adolescents. Due to its tumor biological behavior pattern, osteosarcoma usually generates poor prognosis. Autophagy is an important self-defense mechanism in osteosarcoma. Methods Cell viability in IC50 testing and reve...
Saved in:
Main Authors: | Jiaming He (Author), Wenkan Zhang (Author), Xiaozhong Zhou (Author), Weiqi Yan (Author), Zhan Wang (Author) |
---|---|
Format: | Book |
Published: |
BMC,
2021-11-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux
by: Bin He, et al.
Published: (2021) -
Inactivation of PI3K/Akt promotes the odontoblastic differentiation and suppresses the stemness with autophagic flux in dental pulp cells
by: Sam Young Park, et al.
Published: (2022) -
Ethambutol induces impaired autophagic flux and apoptosis in the rat retina
by: Shun-Ping Huang, et al.
Published: (2015) -
Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma
by: Ying Shen, et al.
Published: (2020) -
Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells
by: Afnan H. El-Gowily, et al.
Published: (2021)