Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid
Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water. Our goal was to formulate SA-transethosomes using thin-film hydration. The prepared formulati...
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MDPI AG,
2023-09-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_63deae04d67c48d294b2a94e136f1fc7 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Yousef A. Bin Jardan |e author |
700 | 1 | 0 | |a Abdul Ahad |e author |
700 | 1 | 0 | |a Mohammad Raish |e author |
700 | 1 | 0 | |a Fahad I. Al-Jenoobi |e author |
245 | 0 | 0 | |a Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid |
260 | |b MDPI AG, |c 2023-09-01T00:00:00Z. | ||
500 | |a 10.3390/pharmaceutics15102391 | ||
500 | |a 1999-4923 | ||
520 | |a Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water. Our goal was to formulate SA-transethosomes using thin-film hydration. The prepared formulations were examined for various parameters. In addition, the optimized formulation was evaluated for surface morphology, in-vitro penetration studies across the Strat M<sup>®</sup>, and its antioxidant activity. The optimized formulation (F5) exhibited 74.36% entrapment efficacy. The vesicle size, zeta potential, and polydispersity index were found to be 111.67 nm, −7.253 mV, and 0.240, respectively. The surface morphology showed smooth and spherical vesicles of SA-transethosomes. In addition, the prepared SA-transethosomes exhibited enhanced antioxidant activity. The SA-transethosomes demonstrated considerably greater penetration across the Strat M<sup>®</sup> membrane during the study. The flux of SA and SA-transethosomes through the Strat M<sup>®</sup> membrane was 1.03 ± 0.07 µg/cm<sup>2</sup>/h and 2.93 ± 0.16 µg/cm<sup>2</sup>/h. The enhancement ratio of SA-transethosomes was 2.86 ± 0.35 compared to the control. The SA-transethosomes are flexible nano-sized vesicles and are able to penetrate the entrapped drug in a higher concentration. Hence, it was concluded that SA-transethosome-based approaches have the potential to be useful for accentuating the penetrability of SA across the skin. | ||
546 | |a EN | ||
690 | |a stratum corneum | ||
690 | |a lipid-based vesicles | ||
690 | |a ultra-deformable vesicles | ||
690 | |a dermal/transdermal | ||
690 | |a Pharmacy and materia medica | ||
690 | |a RS1-441 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Pharmaceutics, Vol 15, Iss 10, p 2391 (2023) | |
787 | 0 | |n https://www.mdpi.com/1999-4923/15/10/2391 | |
787 | 0 | |n https://doaj.org/toc/1999-4923 | |
856 | 4 | 1 | |u https://doaj.org/article/63deae04d67c48d294b2a94e136f1fc7 |z Connect to this object online. |