Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid

Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water. Our goal was to formulate SA-transethosomes using thin-film hydration. The prepared formulati...

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Päätekijät: Yousef A. Bin Jardan (Tekijä), Abdul Ahad (Tekijä), Mohammad Raish (Tekijä), Fahad I. Al-Jenoobi (Tekijä)
Aineistotyyppi: Kirja
Julkaistu: MDPI AG, 2023-09-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Yousef A. Bin Jardan  |e author 
700 1 0 |a Abdul Ahad  |e author 
700 1 0 |a Mohammad Raish  |e author 
700 1 0 |a Fahad I. Al-Jenoobi  |e author 
245 0 0 |a Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid 
260 |b MDPI AG,   |c 2023-09-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics15102391 
500 |a 1999-4923 
520 |a Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water. Our goal was to formulate SA-transethosomes using thin-film hydration. The prepared formulations were examined for various parameters. In addition, the optimized formulation was evaluated for surface morphology, in-vitro penetration studies across the Strat M<sup>®</sup>, and its antioxidant activity. The optimized formulation (F5) exhibited 74.36% entrapment efficacy. The vesicle size, zeta potential, and polydispersity index were found to be 111.67 nm, −7.253 mV, and 0.240, respectively. The surface morphology showed smooth and spherical vesicles of SA-transethosomes. In addition, the prepared SA-transethosomes exhibited enhanced antioxidant activity. The SA-transethosomes demonstrated considerably greater penetration across the Strat M<sup>®</sup> membrane during the study. The flux of SA and SA-transethosomes through the Strat M<sup>®</sup> membrane was 1.03 ± 0.07 µg/cm<sup>2</sup>/h and 2.93 ± 0.16 µg/cm<sup>2</sup>/h. The enhancement ratio of SA-transethosomes was 2.86 ± 0.35 compared to the control. The SA-transethosomes are flexible nano-sized vesicles and are able to penetrate the entrapped drug in a higher concentration. Hence, it was concluded that SA-transethosome-based approaches have the potential to be useful for accentuating the penetrability of SA across the skin. 
546 |a EN 
690 |a stratum corneum 
690 |a lipid-based vesicles 
690 |a ultra-deformable vesicles 
690 |a dermal/transdermal 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 15, Iss 10, p 2391 (2023) 
787 0 |n https://www.mdpi.com/1999-4923/15/10/2391 
787 0 |n https://doaj.org/toc/1999-4923 
856 4 1 |u https://doaj.org/article/63deae04d67c48d294b2a94e136f1fc7  |z Connect to this object online.