Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

• Váldodahkkit: Frances Widjaja (Dahkki), Liang Zheng (Dahkki), Sebastiaan Wesseling (Dahkki), Ivonne M. C. M. Rietjens (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Over 1,000 pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) occur in 3% of all flowering plants. PA-N-oxides are toxic when reduced to their parent PAs, which are bioactivated into pyrrole intermediates that generate protein- and DNA-adducts resulting in liver toxicity and carcinogenic...