IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis.

• Main Authors: Paulo Marcos da Matta Guedes (Author), Fredy R S Gutierrez (Author), Flavia L Maia (Author), Cristiane M Milanezi (Author), Grace K Silva (Author), Wander R Pavanelli (Author), João S Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Chagas disease is a neglected disease caused by the intracellular parasite Trypanosoma cruzi. Around 30% of the infected patients develop chronic cardiomyopathy or megasyndromes, which are high-cost morbid conditions. Immune response against myocardial self-antigens and exacerbated Th1 c...