Investigation of pyrimidine nucleoside analogues as chemical probes to assess compound effects on the proliferation of Trypanosoma cruzi intracellular parasites.

• Main Authors: Melissa Louise Sykes (Author), David Hugh Hilko (Author), Livia Isabella Kung (Author), Sally-Ann Poulsen (Author), Vicky Marie Avery (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi parasites utilise de novo pyrimidine biosynthesis to produce DNA and survive within mammalian host cells. This pathway can be hijacked to assess the replication of intracellular parasites with the exogenous addition of a DNA specific probe. To identify suitable probe compounds for...