Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis

• Main Authors: Mike Aoun (Author), Xiaojie Cai (Author), Bingze Xu (Author), Gonzalo Fernandez Lahore (Author), Michael Yi Bonner (Author), Yibo He (Author), Liselotte Bäckdahl (Author), Rikard Holmdahl (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Animal models for complex diseases are needed to position and analyze the function of interacting genes. Previous positional cloning identified Ncf1 and Clec4b to be major regulators of arthritis models in rats. Here, we investigate epistasis between Ncf1 and Clec4b, two major regulators of arthriti...