Early post-transplant complications following ABO-incompatible kidney transplantation

• Main Authors: Hamza Naciri Bennani (Author), Zhyiar Abdulrahman (Author), Asma Allal (Author), Federico Sallusto (Author), Antoine Delarche (Author), Xavier Game (Author), Laure Esposito (Author), Nicolas Doumerc (Author), Bénédicte Debiol (Author), Nassim Kamar (Author), Lionel Rostaing (Author)
• Format: Book
• Published: Society of Diabetic Nephropathy Prevention, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2251-8363; 2251-8819; 10.15171/jnp.2016.04
• Keywords: kidney transplantation; bleeding; surgical complications; bk virus; blood transfusion; fibrinogen; Pathology; RB1-214; Internal medicine; RC31-1245; Other systems of medicine; RZ201-999
• Source: Journal of Nephropathology, Vol 5, Iss 1, Pp 19-27 (2016)

Background: Living-kidney transplantation is increasing because of the scarcity of kidneys from deceased donors and the increasing numbers of patients on waiting lists for a kidney transplant. Living-kidney transplantation is now associated with increased long-term patient- and allograft-survival rates. Objectives: The purpose of this retrospective study was to identify, in a cohort of 44 ABO-incompatible (ABOi) live-kidney transplant patients, the main complications that occurred within 6 months post-transplantation, and to compare these findings with those from 44 matched ABO-compatible (ABOc) live-kidney transplant patients who were also from our center. Patients and Methods: This single-center retrospective study assessed post-transplantation complications in 44 ABO-i versus 44 matched ABO-c patients. All patients were comparable at baseline except that ABO-i patients had greater immunological risks. Results: During the 6-month post-transplant period, more ABO-i patients presented with postoperative bleeds, thus requiring significantly more blood transfusions. Bleeds were associated with significantly lower values of fibrinogen, platelets, prothrombin time, and hemoglobin levels. Surgical complications, patient- and graft-survival rates, and kidney-function statuses were similar between both groups at 6 months post-transplantation. Conclusions: We conclude that impairment of hemostatic factors at pre-transplant explained the increased risk of a post-transplant bleed in ABO-i patients.