DNA Protection by an Aronia Juice-Based Food Supplement
Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H<sub>2</sub>O<sub>2</sub>-induced DNA strand breaks in isolated peripheral blood lymphocytes. Methods: Ninety-one healthy...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2021-05-01T00:00:00Z.
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| Summary: | Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H<sub>2</sub>O<sub>2</sub>-induced DNA strand breaks in isolated peripheral blood lymphocytes. Methods: Ninety-one healthy volunteers were randomly selected to consume either the food supplement (2 × 25 mL drinking ampules, <i>n</i> = 45) or no supplement (<i>n</i> = 46) daily for eight weeks. Results: Background DNA strand breaks decreased significantly after four and eight weeks of supplement consumption, compared to baseline (<i>p</i> < 0.05), but the overall effect was low, and neither group showed a decrease in total DNA strand breaks. Conversely, supplement consumption clearly reduced H<sub>2</sub>O<sub>2</sub>-induced DNA strand breaks ex vivo (<i>p</i> < 0.001), with statistically significant reductions after four and eight weeks, compared to the control group (<i>p</i> < 0.05). Conclusions: Thus, although consuming antioxidant supplements might produce only marginal immediate benefits under healthy conditions, potential preventive effects warrant further investigation. |
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| Item Description: | 10.3390/antiox10060857 2076-3921 |