Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Hauptverfasser: Line Skute Bråten (Verfasst von), Magnus Ingelman‐Sundberg (Verfasst von), Marin M. Jukic (Verfasst von), Espen Molden (Verfasst von), Marianne Kristiansen Kringen (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2022-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...