Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Κύριοι συγγραφείς: Line Skute Bråten (Συγγραφέας), Magnus Ingelman‐Sundberg (Συγγραφέας), Marin M. Jukic (Συγγραφέας), Espen Molden (Συγγραφέας), Marianne Kristiansen Kringen (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2022-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...