Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Autori principali: Line Skute Bråten (Autore), Magnus Ingelman‐Sundberg (Autore), Marin M. Jukic (Autore), Espen Molden (Autore), Marianne Kristiansen Kringen (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...