Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• 主要な著者: Line Skute Bråten (著者), Magnus Ingelman‐Sundberg (著者), Marin M. Jukic (著者), Espen Molden (著者), Marianne Kristiansen Kringen (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2022-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...