Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Principais autores: Line Skute Bråten (Autor), Magnus Ingelman‐Sundberg (Autor), Marin M. Jukic (Autor), Espen Molden (Autor), Marianne Kristiansen Kringen (Autor)
• Formato: Livro
• Publicado em: Wiley, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...