Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Những tác giả chính: Line Skute Bråten (Tác giả), Magnus Ingelman‐Sundberg (Tác giả), Marin M. Jukic (Tác giả), Espen Molden (Tác giả), Marianne Kristiansen Kringen (Tác giả)
• Định dạng: Sách
• Được phát hành: Wiley, 2022-09-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...