Biomodelo de insuficiencia renal crónica con el uso del tisuacryl en ratas

• Main Author: Carlos Rafael Núñez Cairo (Author)
• Format: Book
• Published: Universidad de Ciencias Médicas de La Habana, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<div style="left: 138.222px; top: 805.562px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.42509);" data-canvas-width="123.98259507745033">Introducción:</div><div style="left: 262.212px; top: 805.562px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.194);" data-canvas-width="260.29296338496675">Con el propósito de mejorar la</div><div style="left: 522.377px; top: 805.562px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19448);" data-canvas-width="268.75782814085545">atención a la Insuficiencia Renal</div><div style="left: 138.222px; top: 825.35px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.1663);" data-canvas-width="292.74106899633745">Crónica (IRC) como problema de sa</div><div style="left: 430.75px; top: 825.35px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19209);" data-canvas-width="298.02184231712636">lud, se han desarrollado numerosas</div><div style="left: 138.222px; top: 845.041px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17014);" data-canvas-width="255.09032727730923">investigaciones experimentales</div><div style="left: 393.319px; top: 845.041px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.15621);" data-canvas-width="235.86694498840762">en biomodelos. Perfeccionar</div><div style="left: 629.016px; top: 845.041px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17317);" data-canvas-width="199.43872508316247">los biomodelos de IRC,</div><div style="left: 138.222px; top: 864.829px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17866);" data-canvas-width="313.5239398306508">es uno de los retos actuales. Los biom</div><div style="left: 451.414px; top: 864.829px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17312);" data-canvas-width="317.91427449346463">odelos de IRC quirúrgicos son los más</div><div style="left: 138.222px; top: 884.519px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20125);" data-canvas-width="687.1126065387585">utilizados y entre sus variantes se deben favorecer la precisión en la instauración y</div><div style="left: 138.222px; top: 904.308px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18963);" data-canvas-width="248.63261218373037">evolución con respecto al tiem</div><div style="left: 386.69px; top: 904.308px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19014);" data-canvas-width="188.04208697624406">po de la insuficiencia.</div><div style="left: 138.222px; top: 924.096px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.37469);" data-canvas-width="83.85588041732468">Objetivo:</div><div style="left: 221.954px; top: 924.096px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20532);" data-canvas-width="302.5342663754578">Evaluar un modelo experimental de</div><div style="left: 524.229px; top: 924.096px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19265);" data-canvas-width="158.62179837371053">Insuficiencia Renal</div><div style="left: 682.823px; top: 924.096px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.1727);" data-canvas-width="139.55143479385774">Crónica en ratas</div><div style="left: 138.222px; top: 943.786px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.2187);" data-canvas-width="208.3984588555492">con el uso del Tisuacryl.</div><div style="left: 138.222px; top: 963.575px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.29683);" data-canvas-width="73.91943148079702">Método:</div><div style="left: 212.109px; top: 963.575px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19186);" data-canvas-width="312.2672329861228">Para ello se utilizaron 90 ratas Wistar</div><div style="left: 524.325px; top: 963.575px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17579);" data-canvas-width="149.32509786969524">distribuidas en se</div><div style="left: 673.563px; top: 963.575px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.2291);" data-canvas-width="154.86632856758845">ries (de 7, 28, 42,</div><div style="left: 138.222px; top: 983.265px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.22021);" data-canvas-width="341.6582201337319">y 60 días) y grupos de trabajo (controles</div><div style="left: 479.681px; top: 983.265px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18283);" data-canvas-width="316.9977900977789">y experimentales) para cada serie. Se</div><div style="left: 138.222px; top: 1003.05px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.1741);" data-canvas-width="231.29754587883468">diseñó un modelo de IRC po</div><div style="left: 369.339px; top: 1003.05px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.211);" data-canvas-width="399.63114870132034">r ablación de 5/6 de la masa renal y se utilizó el</div><div style="left: 138.222px; top: 1022.74px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20302);" data-canvas-width="238.19803851349084">adhesivo tisular Tisuacryl de</div><div style="left: 376.356px; top: 1022.74px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.16915);" data-canvas-width="244.35297190618599">producción nacional como sell</div><div style="left: 620.633px; top: 1022.74px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.1755);" data-canvas-width="213.94131741204927">ante de las superficies de</div><div style="left: 138.222px; top: 1042.53px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20597);" data-canvas-width="306.3157819192904">corte. Se evaluaron la proteinuria de</div><div style="left: 444.298px; top: 1042.53px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.21233);" data-canvas-width="310.3561269816202">24 horas, creatinina plasmática, flujo</div><div style="left: 138.222px; top: 1062.22px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19821);" data-canvas-width="647.031471919626">plasmático renal efectivo (FPRE), intensidad de filtración glomerular (IFG) y la</div><div style="left: 138.222px; top: 1082.01px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.2093);" data-canvas-width="177.76704344948084">fracción de filtración.</div><div style="left: 138.222px; top: 1101.8px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.31111);" data-canvas-width="112.7552542656497">Resultados:</div><div style="left: 251.001px; top: 1101.8px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19641);" data-canvas-width="559.9215021471052">Se apreció un aumento de la Proteinuria y la Creatinina y una caída</div><div style="left: 138.222px; top: 1121.49px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.2137);" data-canvas-width="690.5929682403145">del flujo plasmático renal efectivo y la intensidad de filtración glomerular.
Todas las</div><div style="left: 138.222px; top: 1141.28px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19015);" data-canvas-width="326.10240328617977">variables caracterizaron la instauración</div><div style="left: 464.087px; top: 1141.28px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18114);" data-canvas-width="166.54133049628712">de una insuficiencia</div><div style="left: 630.576px; top: 1141.28px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20215);" data-canvas-width="156.27930983837908">renal crónica en el</div><div style="left: 138.222px; top: 1160.97px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17854);" data-canvas-width="492.62908305500497">modelo con un grado de moderado a ligero con estabilidad.</div><div style="left: 138.222px; top: 1180.76px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.28938);" data-canvas-width="131.51632471019116">Conclusiones:</div><div style="left: 269.815px; top: 1180.76px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20042);" data-canvas-width="282.0981294244145">Se evaluó un modelo de Insuficien</div><div style="left: 551.717px; top: 1180.76px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17232);" data-canvas-width="273.1497906622761">cia Renal Crónica en ratas con el</div><div style="left: 138.222px; top: 1200.45px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20222);" data-canvas-width="331.8129312791908">uso del Tisuacryl, lo que ha permitido co</div><div style="left: 470.031px; top: 1200.45px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17882);" data-canvas-width="335.96397072679">mprobar cómo este modelo ha llegado a</div><div style="left: 138.222px; top: 1220.24px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18408);" data-canvas-width="687.9476980040992">replicar las condiciones en humanos. Se determinan como variables fundamentales<div style="left: 138.222px; top: 115.038px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.19796);" data-canvas-width="340.2208209838378">para indicar la evaluación del grado de In</div><div style="left: 478.22px; top: 115.038px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.20087);" data-canvas-width="317.03034726991706">suficiencia la proteinuria, la creatinina</div><div style="left: 138.222px; top: 134.729px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.17361);" data-canvas-width="237.06993249890795">plasmática, el FPRE y IFG, ju</div><div style="left: 375.188px; top: 134.729px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18656);" data-canvas-width="225.44702204563012">stificando el grado de insufi</div><div style="left: 600.358px; top: 134.729px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.16825);" data-canvas-width="114.48892368199992">ciencia, los cu</div><div style="left: 714.699px; top: 134.729px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.21552);" data-canvas-width="116.68978851853092">ales transitan</div><div style="left: 138.222px; top: 154.517px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18813);" data-canvas-width="340.9924259635092">para este modelo por moderado y ligero.</div><div style="left: 138.222px; top: 197.016px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.2978);" data-canvas-width="144.05571955915457">Palabras clave:</div><div style="left: 282.292px; top: 197.016px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.18296);" data-canvas-width="515.7690931521117">enfermedad renal crónica, insuficiencia renal crónica, modelos,</div><div style="left: 138.222px; top: 216.706px; font-size: 16.2786px; font-family: sans-serif; transform: scaleX(1.1878);" data-canvas-width="257.75350395820027">biomodelos, adhesivo tisular, ci</div>anocrilatos, tisuacryl, rata</div>

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1729-519X