Targeting interleukin‐1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

• Main Authors: Wai W. Cheung (Author), Sheng Hao (Author), Ronghao Zheng (Author), Zhen Wang (Author), Alex Gonzalez (Author), Ping Zhou (Author), Hal M. Hoffman (Author), Robert H. Mak (Author)
• Formato: Livro
• Publicado em: Wiley, 2021-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Ctns−/− mice, a mouse model of infantile nephropathic cystinosis, exhibit hypermetabolism with adipose tissue browning and profound muscle wasting. Inflammatory cytokines such as interleukin (IL)‐1 trigger inflammatory cascades and may be an important cause for cachexia. We emplo...